![]() ![]() Piezo2 channels, implicated in this sensory modality, have been found in dorsal root ganglion (DRG) neurons. Achievements in this quickly expanding field should open a new road for efficient control of Piezo-related diseases including migraine and chronic pain.Ĭonsistent with fast kinetics, Piezo2 channels mediate the short-lasting mechanosensitive processes such as touch. These data include: (i) distribution of Piezo channels in the key elements of the trigeminovascular nociceptive system (ii) the prolonged functional activity of Piezo channels in meningeal afferents providing a mechanistical basis for mechanotransduction in nociceptive nerve terminals (iii) potential activation of Piezo channels by shear stress and pulsating blood flow and (iv) modulation of these channels by emerging chemical agonists and modulators, including pro-nociceptive compounds. In the current review, we present the data that propose the implication of Piezo channels in migraine pain, which has a distinctive pulsatile character. Interestingly, migraine pain is associated with such phenomenon as mechanical hypersensitivity, suggesting enhanced mechanotransduction. Recent studies suggested the role of Piezo channels in migraine pain, which is supposed to originate from the trigeminovascular nociceptive system in meninges. ![]() The functions of Piezo channels range from detection of touch and pain, to control of the plastic changes in different organs. Recently discovered mechanosensitive Piezo channels emerged as the main molecular detectors of mechanical forces. ![]()
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